SciLifeLab Autoimmunity and Serology profiling facility SARS-CoV-2 antibody test statistics

Graphs on this page are based on data as per .

Total serology test numbers

The total number of tests run at SciLifeLab Autoimmunity and Serology profiling facility since the start, split into tests with a positive IgG-result, tests with a negative IgG-result, and R&D tests.

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*The category here denoted as "R&D" (research and development) includes all remaining serum, plasma and saliva samples where we have measured the levels of IgG, IgM or IgA antibodies targeting SARS-CoV-2 proteins. It includes all positive and negative controls, all replicated and rerun of samples and assays, all samples analysed during the continuous development and optimization, technically failed samples and all research associated projects.
**"Proportion positive" here is the proportion of tests with a positive IgG-result out of all tests that were not R&D (i.e., the sum of tests with a positive IgG-result and tests with a negative IgG-result).

Weekly serology test numbers

The number of tests run at SciLifeLab Autoimmunity and Serology profiling facility weekly, split into tests with a positive IgG-result, tests with a negative IgG-result, and R&D tests.

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Cumulative serology test numbers

The sum of all tests run at SciLifeLab Autoimmunity and Serology profiling facility since the start, split into tests with a positive IgG-result, tests with a negative IgG-result, and R&D tests.

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About serology testing at the Autoimmunity and Serology Profiling facility

During early phases of the Covid-19 pandemic, three KTH research groups and the Autoimmunity profiling facility at SciLifeLab set out to develop a serological assay for large scale testing of plasma and serum samples for antibodies to SARS-CoV-2. The work was initiated and coordinated by the three KTH professors Peter Nilsson, Sophia Hober and My Hedhammar.

The development of the assay has been funded by Knut and Alice Wallenberg Foundation, Erling-Persson Family Foundation, SciLifeLab, KTH, Region Stockholm, Atlas Copco, Mercodia, Family Christian and Jennifer Dahlberg, Family Birgitta Klasén.

By comparing and combining large number of variants of SARS-CoV-2 proteins as antigens, a highly sensitive and specific multiplex bead-based assay was established and applied in high throughput with up to 8000 samples analysed per week. The vast majority of samples analysed so far have been collected from health care personnel and within population based studies as well as from personnel in the pharmaceutical and biotechnology industry and also within a long range of research collaborations. Sample providers and research collaborators include Danderyd University Hospital, Karolinska University Hospital, Uppsala University Hospital, Skåne University Hospital, Örebro University Hospital, Sophiahemmet Hospital, Public Health Agency of Sweden, RISE Research Institutes of Sweden, AstraZeneca, Cytiva, SVPH, Karolinska Institutet, KTH, Uppsala University and Lund University.

The SciLifeLab facility has now changed its name to Autoimmunity and Serology Profiling facility.

Publications

Alkharaan, H., Bayati, S., Hellström, C., Aleman, S., Olsson, A., Lindahl, K., Bogdanovic, G., Healy, K., Tsilingaridis, G., De Palma, P., Hober, S., Månberg, A., Nilsson, P., Pin, E., Sällberg Chen, M. Persisting salivary IgG against SARS-CoV-2 at 9 months after mild COVID-19: a complementary approach to population surveys. The Journal of Infectious Diseases, 224 407-414 (2021). https://doi.org/10.1093/infdis/jiab256
Dillner, J., Elfström, K. M., Blomqvist, J., Eklund, C., Lagheden, C., Nordqvist-Kleppe, S., Hellström, C., Olofsson, J., Andersson, E., Jernbom Falk, A., Bergström, S., Hultin, E., Pin, E., Månberg, A., Nilsson, P., Hedhammar, M., Hober, S., Mattsson, J., Arroyo Mühr, L. S., Conneryd Lundgren, K. Antibodies to SARS-CoV-2 and risk of past or future sick leave. Scientific Reports 11, 5160 (2021). https://doi.org/10.1038/s41598-021-84356-w
Dillner, J., Elfström, K. M., Blomqvist, J., Engstrand, L., Uhlén, M., Eklund, C., Boulund, F., Lagheden, C., Hamsten, M., Nordqvist-Kleppe, S., Seifert, M., Hellström, C., Olofsson, J., Andersson, E., Jernbom Falk, A., Bergström, S., Hultin, E., Pin, E., Pimenoff, V. N., Hassan, S., Månberg, A., Nilsson, P., Hedhammar, M., Hober, S., Mattsson, J., Arroyo Mühr, L. S., Conneryd Lundgren, K. High amounts of SARS-CoV-2 precede sickness among asymptomatic healthcare workers. The Journal of Infectious Diseases, 224 jiab099 (2021). https://doi.org/10.1093/infdis/jiab099
Hassan, S. S., Seigerud, Å., Abdirahman, R., Arroyo Mühr, L. S., Nordqvist Kleppe, S., Pin, E., Månberg, A., Hober, S., Nilsson, P., Engstrand, L., Miriam Elfström, K., Blomqvist, J., Conneryd Lundgren, K., Dillner, J. SARS-CoV-2 infections amongst personnel providing home care services for older persons in Stockholm, Sweden. Journal of Internal Medicine, 290 430-436 (2021). https://doi.org/10.1111/joim.13274
Havervall, S., Rosell, A., Phillipson, M., Mangsbo, S. M., Nilsson, P., Hober, S., Thålin, C. Symptoms and Functional Impairment Assessed 8 Months After Mild COVID-19 Among Health Care Workers. JAMA 19, 2015-16 (2021). https://doi.org/10.1001/jama.2021.5612
Hober, S., Hellström, C., Olofsson, J., Andersson, E., Bergström, S., Falk, A. J., Bayati, S., Mravinacova, S., Sjöberg2, R., Yousef, J., Skoglund, L., Kanje, S., Berling, A., Svensson, A-. S., Jensen, G., Enstedt, H., Afshari, D., Xu, L. L, Zwahlen, M., von Feilitzen, K., Hanke, L., Murrell, B., McInerney, G., Karlsson Hedestam, G. B., Lendel, C., Roth, R. G., Skoog, I., Svenungsson, E., Olsson, T., Fogdell-Hahn, A., Lindroth, Y., Lundgren, M., Maleki, K. T., Lagerqvist, N., Klingström, J., Da Silva Rodrigues, R., Muschiol, S., Bogdanovic, G., Arroyo Mühr, L. S., Eklund, C., Lagheden, C., Dillner, J., Sivertsson, Å., Havervall, S., Thålin, C., Tegel, H., Pin, E., Månberg, A., Hedhammar, M., Nilsson, P. Systematic evaluation of SARS-CoV-2 antigens enables a highly speciﬁc and sensitive multiplex serological COVID-19 assay. Clinical and Translational Immunology 10, e1312 (2021). http://dx.doi.org/10.1002/cti2.1312
Kharlamova, N., Dunn, N., Bedri, S. K., Jerling, S., Almgren, M., Faustini, F., Gunnarsson, I., Rönnelid, J., Pullerits, R., Gjertsson, I., Lundberg, K., Månberg, A., Pin, E., Nilsson, P., Hober, S., Fink, K., Fogdell-Hahn1, A. False positive results in SARS-CoV-2 serological tests for samples from patients with chronic inflammatory diseases. Frontiers in Immunology 12, 666114 (2021). https://doi.org/10.3389/fimmu.2021.666114
Klevebro, S., Bahram, F., Elfström, K. M., Hellberg, U., Hober, S., Kebede Merid, S., Kull, I., Nilsson, P., Tornvall, P., Wang, G., Conneryd Lundgren, K., Ponzer, S., Dillner, J., Melén, E. Risk of SARS-CoV-2 exposure among hospital healthcare workers in relation to patient contact and type of care. Scandinavian Journal of Public Health, 1-6 (2021). https://doi.org/10.1177/14034948211022434
Rudberg, A. S., Havervall, S., Månberg, A., Falk, A.J., Aguilera, K., Ng, H., Gabrielsson, L., Salomonsson, A. C., Hanke, L., Murrell, B., McInerney, G., Olofsson J., Andersson, E., Hellström, C., Bayati, S., Bergström, S., Pin, E., Sjöberg, R., Tegel, H., Hedhammar, M., Phillipson, M., Nilsson, P., Hober, S., Thålin, C. SARS-CoV-2 exposure, symptoms and seroprevalence in healthcare workers in Sweden. Nature Communications 11, 5064 (2020). https://doi.org/10.1038/s41467-020-18848-0